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Coward R and Carson C: Tadalafil in the treatment of erectile dysfunction. Therapeutics and Clinical Risk Management.

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It does this by allowing a greater flow of blood into the penis when a man taking the medication is soft erection aroused. It works only with sexual stimulation and does not increase sexual desire.

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Physicians should advise patients to seek immediate medical attention in the event of a sudden loss of vision in one or both eyes. Such an event may be a sign of non-arteritic anterior ischemic optic soft erection NAIONa cause normal erection decreased vision, including permanent loss of vision, that has been reported postmarketing in temporal association with the use of all PDE5 inhibitors.

Tadalafil is predicted to increase the risk of hypotension when given with sapropterin. Saquinavir is predicted to increase the exposure to tadalafil.

In patients with severe renal impairment, avoid use of Tadalafil because of increased Tadalafil exposure AUClimited clinical experience, and the lack of ability to influence clearance by dialysis [see Clinical Pharmacology Because of limited clinical experience in Erectile dysfunction with mild to moderate hepatic cirrhosis Child-Pugh Fix Erectile Dysfunction A or Bconsider a starting dose of Tadalafil 20 mg once daily. Patients with severe hepatic cirrhosis Child-Pugh Class C have not been studied, thus avoid use of Tadalafil in such patients [see Dosage and Administration 2.

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Dextromethorphan; Guaifenesin; Phenylephrine: Moderate The therapeutic effect of phenylephrine may be decreased in patients receiving phosphodiesterase inhibitors. Inhibitors ofsuch as quinidine, may reduce tadalafil clearance. Diltiazem: Moderate Tadalafil is metabolized predominantly by the hepatic cytochrome P 3A4 isoenzyme.

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Following sexual stimulation CIALIS works by helping the blood vessels in your penis to relax, allowing the flow of soft erection into your penis. The result of this is improved erectile function. You and your partner will need to engage in foreplay, just as you would if you were not taking a medicine for erectile dysfunction.

As more and more blood flows to the penis, a pressure is created. This leads to an erection.

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One study on the use of tadalafil for ED showed only a 3. Common adverse events include headache, dyspepsia indigestionand back pain.

These side effects may occur due to the effects of the medication on the PDE-6 enzyme, which is present inside the retina.